There have been only a small number of studies on “detoxification” programs in people. While some have had positive results on weight and fat loss, insulin resistance, and blood pressure, the studies themselves have been of low quality—with study design problems, few participants, or lack of peer review (evaluation by other experts to ensure quality).
A 2015 review concluded that there was no compelling research to support the use of “detox” diets for weight management or eliminating toxins from the body. A 2017 review said that juicing and “detox” diets can cause initial weight loss because of low intake of calories but that they tend to lead to weight gain once a person resumes a normal diet. There have been no studies on long-term effects of “detoxification” programs.